Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Posttranslational modifications of titin from cardiac muscle: how, where and what for? Dahl salt-sensitive (DSS) rats and control rats were fed... Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully... Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. 34117 Kassel . Sie werden durch elastische Titinfilamente zusammengehalten. The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells, where it determines passive tension development and modul... Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. in Europe; GIE féverole, Fachgespräch „Körnerleguminosen in Deutschland“ 2009 JKI Braunschweig, Markergestützte Selektion der optimalen DH-Linie, Link and Ghaouti 2012 Organic faba bean breeding, Genes count, pyramiding alleles, Summer Seminar 2014, Schnell Zweisatz-Gitter-Anlage Versuchsanlage, 1999 Geiger Populationsgenetik + Pflanzenzüchtung, Directories of courses and people (UniVZ), DFG Projekt: "Molecular and quantitative-genetic analysis of seed size in faba bean (, Abo-Vici: "Breeding and agronomy of novel, low-vicine faba beans and adoption as domestic protein feed", Faba bean: Genetic analysis of the Ascochyta-resistance of faba bean (, Faba bean: genetic increase and stabilization of grain yield via optimum exploitation of heterosis; Analysis of pollination and pollinators, Breeding research on the mixed cropping of faba bean and wheat, Regional chicken races, regional protein feed ("PorReE"), Population structure und breeding method in case of partial allogamy, Research on faba bean drought and weed tolerance in Morocco. He has written four works of comparative literature and psychology of art, now considered standards of their genre. Göttingen. Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Academician at Göttingen Academy of Sciences, Fellow of the International Society for Heart Research (ISHR), Franz Maximilian Groedel Research Prize of the German Cardiac Society, Heisenberg Fellowship from German Research Foundation. We used hetero‐ and homozygous R349P desmin... Background With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. Desmin is the major intermediate filament (IF) protein in human heart and skeletal muscle. Here we demonstrate that deficiency of SPRED2, an intracellular repressor of ERK-MAPK signaling markedly expressed in human heart, resulted in impaired autophagy, heart failure, and shortened lifespan. Die Aktin- und Myosinfilamente treten durch Bildung bzw. Wolfgang. Objective: 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0. We argue that, by comparing tissues from failing human hearts with age-matched non-fail... Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Current projects: Public relations activity at Reinshof TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. Sorry, you need to be a researcher to join ResearchGate. November 1940 in Ludwigshafen; † 7. Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. Here, we characterise the molecular stru... Background März 1949 geboren. The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. E-Mail: neurologie.sekretariat(at)med.uni … Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. Methods: Here we show that homozygous deletion (homozygous tm1a, tm1b or tm1d alleles) of Myo18a in mouse is embryonic lethal. 1984 - 1989 Universities of Tübingen, Munich and Göttingen, law studies. Rathaus. Anbieter: Volksbank Kassel Göttingen eG. Left atrial (LA) compliance and contractility influence left ventricular stroke volume. English, German. Universität Göttingen. Winda Puspitasari, 2017: Association analyses to genetically study reproduction and seed quality features of faba bean (. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. Wolfgang. We combined a geno... Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. agric. nat., University of Göttingen. Supplementary Figure Set for Unger et al., Acta Neuropathol Commun. The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. Only verified researchers can join ResearchGate and send messages to other members. Wolfgang König hat die Professur für Betriebswirtschaftslehre, insbesondere Wirtschaftsinformatik und Informationsmanagement an der Goethe-Universität Frankfurt inne. Zenker Ofenbackform Auflaufform mit Buch Low-Carb-Aufläufe von Wolfgang Link Mit dem 2-teiligen Set mit Ofenbackform und Low-Carb-Aufläufe Buch von Zenker können sie nicht nur tolle Rezepte nachkochen, sondern können auch noch Ihrer Traumfigur ein Stückchen näherkommen. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Die Telefonnummer 0551 9 48 00 finden Sie ganz oben auf der Seite. Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. With this reproductive behaviour, breeding methods appropriate for faba bean should be general solutions of which the methods for self-fertilizing and cross-fertilizing crops should be just extreme, marginal cases. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. Friedhof Junkerberg Heinrich-A.-Zachariä-Bogen 12 37077 Göttingen Kontakt: Telefon: 0551/400-5210 Telefax: 0551/400-5222 E-Mail: w.giesse@goettingen.de All rights reserved. MPS develops and builds scientific instruments that investigate solar system bodies. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. In the original version of this article, the name of one of the authors is not correct. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. Join ResearchGate to find the people and research you need to help your work. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) towards an adult phenotype under defined conditions. Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. The giant sarcomere protein titin is important in both heart health and disease. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart, Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator, Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function, A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues, Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D, The Specific Cleavage of Titin Springs to Quantify the Contribution of Titin to Myocardial Passive Stiffness, Erratum: Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis, Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients, Symmetric dimethylarginine in dysfunctional high-density lipoprotein mediates endothelial glycocalyx breakdown in chronic kidney disease, Funktionelle Analyse zweier neuer Desmin-Mutationen, assoziiert mit familiären Kardiomyopathien, Arrhythmien und einem erhöhten Risiko für plötzlichen Herztod, Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function, P.78Sarcomeric pathology induced by homozygous expression of the myofibrillar myopathy - associated p.W2711X filamin C mutant, P.80Imbalances in protein homeostasis caused by mutant desmin, Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis, Abstract 330: A HaloTag-TEV Genetic Cassette for Mechanically Probing Native Titin, Abstract 466: Myopathy Causing Bag3 P209L Protein Leads to Restrictive Cardiomyopathy Caused by Aggregate Formation and Sarcomere Disruption in Cardiomyocytes, Cardiac α-Actin ( ACTC1 ) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy, The Translational Landscape of the Human Heart, Sarkomerische Pathologie durch die homozygote Expression der Myofibrilläre Myopathie-assoziierten W2711X Filamin-C Mutante, Mutiertes Desmin verursacht komplexe Störungen der muskulären Proteinhomeostase, The continuous heart failure spectrum: Moving beyond an ejection fraction classification. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. To o... Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. Webseiten der Georg-August-Universität Göttingen. A CARDIAC α-ACTIN (ACTC1) GENE MUTATION CAUSES ATRIAL-SEPTAL DEFECTS ASSOCIATED WITH DILATED CARDIOMYOPATHY, A HaloTag-TEV genetic cassette for mechanical phenotyping of native proteins, Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload, A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart, SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy, Specific Cleavage of the Titin Springs In Situ Uncovers the Role of Titin-Based Force in Sarcomere Structure and Muscle Contraction, Treatments targeting inotropy: A position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European Society of Cardiology Heart failure/cardiomyopathy, Early myocardial changes induced by doxorubicin in the non-failing dilated ventricle, Titin as a force generating muscle protein under regulatory control. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Rudolf-Schwander-Str. Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. Descriptive terms such as 'HFrEF' (... Titin is a giant elastic protein expressed in the contractile units of striated muscle cells, including the sarcomeres of cardiomyocytes.