Taking St. John's wort with ketamine might reduce the drug's anesthetic effect. Anyone who is taking any other medications and wishes to use St Johnâs wort is advised to check with their doctor first. Like birth control pills, if you're female. I know people are different but there was mo ill effects whatsoever of mixing the two that i could note. While St. Johnâs wort appears to be a relatively safe supplement, there are a few things to consider before taking it. Ketamine (Ketalar). 1 year ago. 4. share. In some people, it may have an opposite affect. Taking St. John's wort with this antihistamine might cause too much of the drug to build up in your body, worsening usual side effects. St. john's wort has an average rating of 7.9 out of 10 from a total of 97 ratings for the treatment of Depression. ... best. St. John's wort and anxiety are connected mostly as a possible remedy to help people with anxiousness. Question: Close. When taken alone, St Johnâs wort has very few side-effects. Side effects with St. Johnâs wort are generally mild and can include stomach upset, hives, skin rashes, fatigue, restlessness, headache, dry mouth, dizziness and confusion. Any experience with st john wort? Dry mouth 7. St. Johnâs wort is sold as a dietary supplement in the United States, where the standards for selling supplements are less strict than the standards for prescription or over-the-counter drugs. Taking St. John's wort with this heart medication can reduce the drug's effect. Safety and side effects of St. John's wort: Although generally safe, St. John's wort can cause a range of side effects. level 2. 1 year ago. Fexofenadine (Allegra Allergy). Archived. Any experience with st john wort? Because of its anti-inflammatory properties, it has been applied to the skin to help heal wounds and burns. Report Save. Posted by 1 year ago. Research shows the Hyperforin found in St. Johnâs wort is a potent noncompetitive inhibitor of CYP2D6 activity and competitive inhibitor of CYP2C9 and CYP3A4 activity. Side Effects. Here's what to know about St. John's wort. However, St Johnâs wort interacts with many prescription medications, either affecting how these medications work or producing serious side-effects. level 1. Be careful with st Johns wort, it can interact with a lot of medications etc. report. 3. 77% of those users who reviewed St. john's wort reported a positive effect, while 14% reported a negative effect. St. John's wort is a plant with yellow, star-shaped flowers. St. John's wort (Hypericum perforatum) has a history of use as a medicine dating back to ancient Greece, where it was used for a range of illnesses, including various nervous disorders.St. St. John's wort (Hypericum perforatum) is a flowering plant in the Hypericaceae family named for its bright yellow flowers that were said to bloom for the first time around St. John the Baptist's birthday.The word "wort" means "plant" in Old English. John's wort also has antibacterial, antioxidant, and antiviral properties. St. Johnâs wort (Hypericum perforatum), a plant that grows in the wild, has been used for centuries for mental health conditions.Itâs widely prescribed for depression in Europe. St. John's Wort 900 mg in the evening 5HTP 100 mg in the evening L-Tyrosine 3,000 mg in the morning I have read that the first two of these supplements, St John's Wort and 5HTP, both fortify the brains 'serotonin pathways'. The nice thing is that St Johnâs Wort doesnât appear to interact with most conventional drugs. User Reviews for St. john's wort to treat Depression.